Onychomycosis, or a fungal nail infection, can be painful, disfiguring, and difficult to treat. Fortunately, there are prescription medications that can help. One of these is efinaconazole. The brand name for efinaconazole is Jublia.
Efinaconazole (Jublia) is an antifungal medication applied directly to the affected nails. It works by stopping the growth of the fungus.
This article will give you a comprehensive overview of efinaconazole, how it’s used, how to apply it, what to watch out for, and what side effects you might experience.
Brand name and description
Efinaconazole is an antifungal medication in the azole family.
In the United States, efinaconazole is available by prescription only under the brand name Jublia.
Jublia is a topical solution you apply directly to the affected area.
Dosing and Uses
The brand-name medication Jublia contains the active ingredient efinaconazole. It’s a topical antifungal medication used to treat onychomycosis (toenail fungus), though fungi can also affect fingernails.
Jublia is effective against two common types of fungus, Trichophyton rubrum and Trichophyton mentagrophytes.
Dosage
For adults and children ages 6 and up, the recommended dosage is to apply Jublia every day for 48 weeks.
You’ll apply the solution to the affected toenail (or toenails) and the skin around it, including the cuticle and the skin under the nail.
How to use and store efinaconazole (Jublia)
How to apply
Efinaconazole (Jublia) is a topical medication. That means you spread it on your skin. Don’t take it by mouth, and don’t put it in your eyes or vagina.
Use the brush applicator to apply the medication as directed. Be sure to wash your hands before and after you use the medicine.
How to store
Store efinaconazole (Jublia) as directed. Be sure to keep it away from heat and flame, since this product is flammable.
How does efinaconazole work?
Efinaconazole is a triazole antifungal medication.
It works by blocking a fungal enzyme called lanosterol 14α-demethylase, which plays a role in the creation of ergosterol.
Ergosterol is an important part of fungal cell membranes.
How does efinaconazole behave in the body?
When people use efinaconazole:
- The highest concentration in the blood on day 28 is 0.67 ng/mL.
- AUC is 12.15 ng•h/mL. (AUC is a measure of drug exposure.)
- Half-life on day 7 is 29.9 hours. (Half-life is how long it takes for half of the drug to be eliminated from the body.)
Warnings and Precautions
Before you start using efinaconazole, here are some things to keep in mind:
Contraindications
It’s important to let your doctor know about any conditions you have or medicines you take, so they can be sure efinaconazole is right for you.
Cautions
- Efinaconazole (Jublia) is for external use only. Do not swallow.
- Avoid getting efinaconazole in your eyes, mouth, or vagina.
- Tell your doctor about any allergies you have.
- Efinaconazole is flammable, so keep it away from heat, flames, and smoking.
- Don’t use nail polish or other cosmetic nail products while you’re using efinaconazole, as they could contribute to gel nail fungus.
- See your doctor regularly to monitor your treatment progress and watch out for side effects.
What are the side effects of Jublia?
Like all medications, Jublia may come with unwanted side effects. Be sure to discuss potential side effects with your doctor before starting this medication.
Most people who use Jublia don’t experience any side effects at all.
Common side effects (1-10%)
The most common side effects include:
- skin reactions at the application site, such as dermatitis (2.2%), small blisters (1.6%), and pain (1.1%)
- ingrown toenail (2.3%)
Less common side effects
More serious side effects can occur, but these are rare.
Be sure to tell your doctor immediately about any unusual toenail problems or any concerning symptoms at the site where you’re applying the medication.
Who can use efinaconazole?
Children
The FDA has approved Jublia for use by children ages 6 and older.
Studies of children haven’t revealed any pediatric-specific problems that would limit how well the medicine works.
Older adults
Older adults should use Jublia with caution.
Studies haven’t shown any age-related problems that would limit how well it works.
Pregnant and breastfeeding people
We don’t have much information about using Jublia during pregnancy. Animal studies haven’t shown any negative effects when using high doses.
We also don’t know much about using Jublia while breastfeeding. Talk to your doctor before using it if you are breastfeeding.
Drug Interactions
Before you start using Jublia, you should tell your doctor about all the medications you’re taking, including any over-the-counter medicines, supplements, and herbal remedies.
It’s important to discuss any potential drug interactions with your doctor or pharmacist to ensure Jublia is safe for you to use.
Summary
Efinaconazole, sold under the brand name Jublia, is a topical medication that you can apply directly to your toenails to treat onychomycosis, or toenail fungus.
To get the best results, you’ll need to carefully follow your doctor’s instructions about how to apply the medication and how long to continue treatment.
As with any medication, you should be aware of potential side effects and precautions, and you should always talk to your doctor or other healthcare provider if you have any questions or concerns.