Fluconazole and itraconazole are both antifungal medications frequently prescribed to treat a wide range of fungal infections. Both are azole antifungals, meaning they work in similar ways to prevent fungi from growing.
Any time you take multiple medications, it’s critical to understand how those drugs might interact with each other. When two drugs interact, one can change how the other works in your body, increasing its toxicity or reducing its effectiveness.
So, can fluconazole and itraconazole be taken together safely? In general, no. Both fluconazole and itraconazole inhibit CYP3A enzymes. CYP3A enzymes are responsible for metabolizing a broad range of medications. When these enzymes are inhibited, the levels of those other medications can increase, potentially leading to side effects.
This article will explore the potential for interaction between these two antifungal medications, discuss the available research, and provide guidance for your doctor as they consider which medication is the right choice for you.